A group of physicians from throughout the United States, Canada, Australia, and New Zealand, have formed a collaborative effect to identify genes that may be important in the development of aneurysms in the blood vessels of the brain. This study of affected families, known as the Familial Intracranial Aneurysm (FIA) study, which is sponsored by the National Institutes of Health and initally involved approximately 450 families. The recruitment of these families has now been completed.
FIA II will involve an additional 200 families plus 1800 subjects with an Intracranial Aneurysm but no family history. These families and individuals will be used to replicate the findings of FIA I. FIA II will take place in North America only.
To be eligible to participate in this study, families must have two or more affected pairs of siblings (brothers/sisters) or 3 or more family members affected with intracranial aneurysms. Subjects can participate if they do not have an eligible family history, but do have a confirmed intracranial aneurysm.
Participants will be asked to complete a family history questionnaire (if they have a family history) and a medical history questionnaire. They will also have their blood pressure measured and will give a small sample of blood. In addition, medical records will be requested to confirm the diagnosis of intracranial aneurysms. There will be no monetary compensation for participation.
Participation in this project is voluntary. To request additional information or to enroll in this study please contact Laura R. Sauerbeck at University of Cincinnati, at 513-558-1742 or 1-(800) 503-3427. Information about the study can also be obtained by email.